A recent article in the New York Times (Sept 25, 1988, p 13) highlighted findings on the transplantation of retinal pigment epithelial (RPE) cells as a means of "treating" retinal degeneration in the Royal College of Surgeons (RCS) rat. The article stated that this procedure not only was successful in treating retinal degeneration in this animal model but also held promise for success in treating human degenerative retinal disorders, including retinitis pigmentosa and age-related macular degeneration.
James E. Turner, PhD, and Linxi Li, MD, from the Bowman Gray School of Medicine, Winston-Salem, NC, have successfully transplanted healthy RPE cells from a normal group of rats into the subretinal space of a congenic (similar hereditary background) strain of RCS rats with retinal degeneration.1 After performing a sclerotomy and penetrating the choroid in the superior quadrant of the eye, the investigators injected a 1-μL suspension of approximately 40 000 to 60
Fishman GA. Transplantation of Retinal Pigment Epithelial CellsScientific Advance and Social Responsibility. Arch Ophthalmol. 1988;106(12):1667-1668. doi:10.1001/archopht.1988.01060140839021