• Pigment has been associated with glaucoma in pigment dispersion syndrome and in intraocular lens-associated pigment dispersion. Human eyes with segmental pigmentation of the trabecular meshwork may provide a controlled model to study the effects of pigment on the meshwork. Nine normal human eye bank eyes with segmental pigmentation of the trabecular meshwork were examined for pigment-associated differences in trabecular cellularity or morphology. Cellularity was examined with four methods: cells per histologic section, cells per length of tissue, cells per overall area, and cells per solid tissue. The simplest method, cells per histologic section, gave results equivalent to the other methods. No differences in cellularity or morphology were found between pigmented and nonpigmented areas.
Johnson DH. Does Pigmentation Affect the Trabecular Meshwork?. Arch Ophthalmol. 1989;107(2):250-254. doi:10.1001/archopht.1989.01070010256032