To the Editor.
—Treatment of progressive cytomegalovirus (CMV) retinitis with intravitreal injections of ganciclovir has been advocated as an effective and safe form of therapy in patients in whom severe neutropenia precludes adequate intravenous ganciclovir therapy.1,2 A patient with acquired immunodeficiency syndrome (AIDS) complicated by progressive CMV retinitis of the right eye underwent a course of intravitreal treatment with ganciclovir because of persistent neutropenia resulting from intravenous ganciclovir therapy. During the ninth week of therapy the patient developed a bacterial endophthalmitis that required pars plana vitrectomy and a course of systemic antibiotic therapy.
Report of a Case.
—A 36-year-old homosexual man was diagnosed as having AIDS in 1987 when he developed Pneumocystis carinii pneumonia. At this time he was found to have CMV retinitis of the right eye, which was treated with an initial induction course of ganciclovir followed by maintenance therapy. The progression of the retinitis was arrested,
Heinemann M. Staphylococcus epidermidis Endophthalmitis Complicating Intravitreal Antiviral Therapy of Cytomegalovirus Retinitis. Arch Ophthalmol. 1989;107(5):643-644. doi:10.1001/archopht.1989.01070010661016