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June 1989

MRI in Optic Neuritis-Reply

Author Affiliations

Tampa, Fla

Arch Ophthalmol. 1989;107(6):789. doi:10.1001/archopht.1989.01070010811004

In Reply.  —My editorial on the Optic Neuritis Treatment Trial (ONTT) summarized the study design, but in such a format, many of the details of study procedures and subgroup analyses could not be discussed.Dr Blackwell cites the study by Miller et al that suggested that in cases of acute optic neuritis, MRI localization of the involved portion of the optic nerve and the extent of involvement may have prognostic value. My colleagues and I are certainly aware of this study and share Dr Blackwell's opinion about its potential significance. Miller et al used a fat-suppression scanning technique to identify lesions in the optic nerve. There is recent evidence that gadolinium-enhanced MRI can identify acute demyelination in the brain in patients with multiple sclerosis.1,2 We have found that with this technique, optic nerve lesions can be identified in acute optic neuritis (Figure). At the present time, we are investigating

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