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Article
June 1989

Orbital Inflammation and Optic Neuropathies Associated With Chronic Sinusitis of Intranasal Cocaine AbusePossible Role of Contiguous Inflammation

Author Affiliations

From the Oculoplastics Division (Drs Goldberg, McFarland, and Shorr) and the Division of Neuro-ophthalmology (Drs Weisman, Krauss, and Hepler), Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, Calif.

Arch Ophthalmol. 1989;107(6):831-835. doi:10.1001/archopht.1989.01070010853028
Abstract

• Three cases of long-standing intranasal cocaine abuse were associated with orbitopathy or optic neuropathy. All three cases were characterized by chronic sinusitis. Histopathologic examination of involved sinus and orbital tissues revealed chronic and acute nonspecific inflammation, with no evidence of unusual infections or of idiopathic midline destructive disease. In two of the cases, there was radiographic evidence of contiguous orbital inflammation associated with sinusitis. The inflammatory orbital process in these two cases was steroid responsive, but in one case recurrent inflammation occurred in response to steroid tapering. One patient suffered a complete loss of vision in the involved eye due to fulminant orbital inflammation and optic nerve dysfunction.

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