• Three patients who had been treated with transscleral cryotherapy to the avascular retina for stage 3+ retinopathy of prematurity with threshold disease had total rhegmatogenous retinal detachments develop. In each case, the retinal detachment developed more than 1 year after treatment and resulted from a tear at the junction of the treated and untreated retina. Rhegmatogenous retinal detachment is a late complication of transscleral cryotherapy that to our knowledge has not previously been documented.
Greven CM, Tasman W. Rhegmatogenous Retinal Detachment Following Cryotherapy in Retinopathy of Prematurity. Arch Ophthalmol. 1989;107(7):1017-1018. doi:10.1001/archopht.1989.01070020079034