• Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.
Howard MA, Dryja TP, Walton DS, Albert DM. Identification and Significance of Multinucleate Tumor Cells in Retinoblastoma. Arch Ophthalmol. 1989;107(7):1025-1030. doi:10.1001/archopht.1989.01070020087037