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Article
September 1989

Concentration Change and Activity of Fluorouracil in the External Segment of the Eye After Subconjunctival Injection-Reply

Author Affiliations

Tokyo, Japan

Arch Ophthalmol. 1989;107(9):1277. doi:10.1001/archopht.1989.01070020346004
Abstract

In Reply.  —Dr Ball's letter correctly addressed some of the concerns that we had in extrapolating our results obtained using normal rabbit eyes to the clinical situation. The main purpose of our article was to report that 24 hours after the subconjunctival injection of 5 mg of fluorouracil, its levels in the cornea, sclera, and conjunctiva were still above the reported fluorouracil concentrations for 50% inhibition of cultured fibroblast proliferation levels, which may have clinical implications for the safe use of this drug. As expressly stated in the "Comment" section, it is difficult to estimate the fluorouracil levels postoperatively in the human eye with glaucoma from the results we obtained.1 There are too many differences in the conditions between normal rabbit eyes and human eyes with glaucoma postoperatively. For example, we injected fluorouracil through the superior rectus muscle belly to minimize reflux.1 In patients, this method of injection

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