• In a review of 10 patients with superior segmental optic nerve hypoplasia, all of whom were the children of diabetic mothers, 17 of 20 eyes had one or more of four characteristic findings in the optic disc: relative superior entrance of the central retinal artery, pallor of the superior disc, superior peripapillary halo, and thinning of the superior peripapillary nerve fiber layer. We believe that the presence of these four signs of superior segmental optic nerve hypoplasia strongly suggests maternal diabetes.
Kim RY, Hoyt WF, Lessell S, Narahara MH. Superior Segmental Optic HypoplasiaA Sign of Maternal Diabetes. Arch Ophthalmol. 1989;107(9):1312-1315. doi:10.1001/archopht.1989.01070020382040