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November 1989

Eye Involvement in Junctional Epidermolysis Bullosa

Author Affiliations

From the Department of Ophthalmology and the Institute of Dermatology, United Medical and Dental Schools, St Thomas' Hospital, London, England.

Arch Ophthalmol. 1989;107(11):1635-1637. doi:10.1001/archopht.1989.01070020713034

• The ocular findings in a group of five patients with the nonlethal form of junctional epidermolysis bullosa are presented. A history of recurrent corneal erosion and the presence of corneal scarring were the most common findings. We discuss the possible mechanisms of the ocular changes and describe how the recent application of monoclonal antibody probes to components of the basement membrane are helping to elucidate the basic defect in this condition.