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—The comments of Yuzbasiyan-Gurkan and Brewer concerning their clinical experiences with the relative safety of long-term oral zinc administration are illuminating. It is reasonable to recommend the consumption of a zinc preparation with less potential for gastric irritation so that the supplement may be taken at a time when its absorption is promoted. Additional supplementation with 1 mg of copper daily also appears reasonable.Yuzbasiyan-Gurkan and Brewer alluded to the variability of zinc uptake. This would likely be a problem regardless of the type of preparation. It is suspected, but not known with certainty, that the absorption of trace minerals may vary with age, as it does with a variety of disease processes. More needs to be understood concerning this matter.A single trace metal nutrient does not exist in vivo in isolation. It participates in metabolic and functional links involving a variety of other elements. It seems
Newsome DA. The Therapeutic Use of Zinc in Macular Degeneration-Reply. Arch Ophthalmol. 1989;107(12):1723-1724. doi:10.1001/archopht.1989.01070020805005