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January 1990

India-US Case-Control Study of Age-Related Cataracts

Author Affiliations

Oxford, England

Arch Ophthalmol. 1990;108(1):13. doi:10.1001/archopht.1990.01070030015004

To the Editor.  —I read with interest the article by Dr Mohan and colleagues1 on their carefully conducted case-control study of cataract. Their confirmation of the apparent protective effect of aspirin against cataract was particularly exciting. In our own work we found an entire group of nonnarcotic analgesics, principally aspirin (acetylsalicylic acid), ibuprofen, and acetaminophen (paracetamol; N-acetyl-p-aminophenol) associated with protection against cataract.2,3 The results of Mohan et al indicate that any dose of aspirin protects (one or more tablets per month), a result we found in Oxford, England (any dose at any time; J. J. H., M. Egerton, and R. S. Harding, unpublished data, 1988). Furthermore, we showed that even the lowest quartile of doses of aspirin and acetaminophen were associated with the protective effect (67% and 43% protection, respectively). The upper limits of these quartiles were equivalent to taking one tablet a day of

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