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Article
February 1990

The Relationship of Puberty to Diabetic Retinopathy

Author Affiliations

From the Retinal Vascular Center (Drs Murphy, Nanda, and Patz and Ms Vitale) and the Biostatistics Center (Ms Enger) of The Wilmer Ophthalmological Institute and the Department of Pediatrics (Dr Plotnick), The Johns Hopkins Medical Institutions, Baltimore, Md.

Arch Ophthalmol. 1990;108(2):215-218. doi:10.1001/archopht.1990.01070040067032
Abstract

• The presence of background and preproliferative retinopathy in 70 patients with type I diabetes was correlated with their pubertal development. Pubertal status was assessed by pediatricians using the sexual maturity ratings of Tanner. In young diabetics with comparable disease duration (5 to 10 years), postpubertal children had a greater prevalence of retinopathy than those who were not sexually mature. After adjusting for duration of diabetes and sex, the relative odds of having retinopathy in the postpubescent group relative to the prepubescent or pubescent groups was 4.8 (95% confidence interval: 1.5 to 15.3). This study suggests that minimal retinopathy in children is not rare and that postpubescent children have a greater prevalence of diabetic retinopathy than do prepubescent children with similar diabetes duration.

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