When considering a diagnosis of periorbital cellulitis, findings of a systemic evaluation of the patient must be taken into account. Although leukemia is characterized by infiltration of bone marrow and blood with immature leukocytes, other organs may be involved, including the skin. We describe a patient with acute myeloblastic leukemia who clinically appeared to have periorbital cellulitis.
Report of a Case.
—An 85-year-old man was evaluated for bilateral periorbital edema and erythema that had been present for 2 weeks. His past history included multiple myeloma diagnosed 3 years earlier. Three months prior to evaluation, he developed myelodysplastic syndrome, which was treated with chemotherapeutic agents and corticosteroids. The patient had refractory anemia and within 2 weeks prior to evaluation was found to have excess blasts in his peripheral blood consistent with acute myeloblastic leukemia. The patient was initially treated with systemic ciprofloxacin hydrochloride for presumed infectious periorbital cellulitis and failed to
Grossniklaus HE, Wojno TH. Leukemic Infiltrate Appearing as Periorbital Cellulitis. Arch Ophthalmol. 1990;108(4):484. doi:10.1001/archopht.1990.01070060032016