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December 1990

Retinal Toxicity of Intravitreal Gentamicin

Author Affiliations

From the Retina Vascular Unit Service (Drs Brown, Shakin, and Gruber) and the Pathology Service (Dr Eagle and Ms Arbizio), Wills Eye Hospital, Thomas Jefferson University School of Medicine, Philadelphia, Pa.

Arch Ophthalmol. 1990;108(12):1740-1744. doi:10.1001/archopht.1990.01070140094037

• The short- and long-term effects of a 10-mg dose of intravitreal gentamicin were studied in the subhuman primate eye with regard to the changes in clinical appearance, fluorescein angiography, electroretinography, histopathologic finding, and electron microscopy. The gentamicin produced retinal whitening with a cherry-red spot, generalized vascular incompetence, diffuse retinal necrosis, thrombosis of the large retinal blood vessels, widespread loss of the retinal capillary pericytes and endothelial cells, and a rapid extinction of the electroretinogram.