To the Editor.
—Subconjunctival fluorouracil has been successfully used following filtering surgery for glaucoma secondary to uveitis1,2 by preventing filtering bleb scarring through the inhibition of fibroblast proliferation. Based on the known beneficial effect of systemic cytotoxic drugs on certain types of uveitis, we decided, following such filtering surgery, to treat anterior uveitis with fluorouracil simultaneously with its use in the prevention of bleb scarring.
Report of Cases.
—Three patients (Table) experienced chronic, unilateral, mild (1+ cell and flare) to severe (3+ cell and flare) anterior uveitis. All three were being treated with local and systemic steroids. Due to uncontrolled glaucoma, filtering surgery was performed in each eye, and topical 0.1% dexamethasone and 1% atropine sulfate drops were administered four times a day. In addition, 5 mg of fluorouracil in 0.5-mL saline was repeatedly injected inferiorly, 180° away from the surgical site. Frequency (one to two times per day)
Ophir A, Ticho U. Remission of Anterior Uveitis by Subconjunctival Fluorouracil. Arch Ophthalmol. 1991;109(1):12-13. doi:10.1001/archopht.1991.01080010014005