• We describe a newborn with congenital cystic eye, contralateral persistent hyperplastic primary vitreous, and cerebrocutaneous abnormalities. The cerebrocutaneous abnormalities consisted of agenesis of the corpus callosum, mid-brain deformity, malformed sphenoid bone, right upper eyelid coloboma, and a left periocular hamartoma. The results of karyotype analysis of the patient and his parents were normal. The association of congenital cystic eye with contralateral persistent hyperplastic primary vitreous has not been previously reported, to our knowledge. Although no unifying diagnosis exists for the collection of anomalies demonstrated in this patient, the term cranial ectodermopathy broadly classifies most of the defects.
Pasquale LR, Romayananda N, Kubacki J, Johnson MH, Chan GH. Congenital Cystic Eye With Multiple Ocular and Intracranial Anomalies. Arch Ophthalmol. 1991;109(7):985-987. doi:10.1001/archopht.1991.01080070097044