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August 1991

Selective α2-Adrenerigc Agonists B-HT 920 and UK14304-18Effects on Aqueous Humor Dynamics in Monkeys

Author Affiliations

From the Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY.

Arch Ophthalmol. 1991;109(8):1158-1162. doi:10.1001/archopht.1991.01080080118044

• Selective α2-adrenergic agonists UK14304-18 and B-HT 920 were evaluated in the eyes of cynomolgus monkeys. In normal monkeys, unilateral topical application of 0.3%, 0.5%, or 1% UK14304-18 or B-HT 920 reduced (P<.05) intraocular pressure bilaterally up to 9.9±1.2 mm Hg (mean±SEM) and 8.4±1.4 mm Hg in treated and contralateral eyes, respectively. Five-day twice-daily 0.5% UK14304-18 administration reduced (P<.05) intraocular pressure up to 49% in eight glaucomatous monkeys. In eight normal monkeys, 0.5% B-HT 920 and 0.5% UK14304-18 produced no alterations in outflow facility. Following unilateral application of 0.5% B-HT 920 or 0.5% UK14304-18, fluorophotometrically measured aqueous humor production was reduced (P<.05) bilaterally up to 67% compared with baseline values. Also, 0.5% UK14304-18 reduced (P<.025) systolic and diastolic blood pressure. UK14304-18 and B-HT 920 seem to reduce intraocular pressure by decreasing aqueous production. They are potential new agents for the treatment of glaucoma.