• Selective α2-adrenergic agonists UK14304-18 and B-HT 920 were evaluated in the eyes of cynomolgus monkeys. In normal monkeys, unilateral topical application of 0.3%, 0.5%, or 1% UK14304-18 or B-HT 920 reduced (P<.05) intraocular pressure bilaterally up to 9.9±1.2 mm Hg (mean±SEM) and 8.4±1.4 mm Hg in treated and contralateral eyes, respectively. Five-day twice-daily 0.5% UK14304-18 administration reduced (P<.05) intraocular pressure up to 49% in eight glaucomatous monkeys. In eight normal monkeys, 0.5% B-HT 920 and 0.5% UK14304-18 produced no alterations in outflow facility. Following unilateral application of 0.5% B-HT 920 or 0.5% UK14304-18, fluorophotometrically measured aqueous humor production was reduced (P<.05) bilaterally up to 67% compared with baseline values. Also, 0.5% UK14304-18 reduced (P<.025) systolic and diastolic blood pressure. UK14304-18 and B-HT 920 seem to reduce intraocular pressure by decreasing aqueous production. They are potential new agents for the treatment of glaucoma.
Serle JB, Steidl S, Wang R, Mittag TW, Podos SM. Selective α2-Adrenerigc Agonists B-HT 920 and UK14304-18Effects on Aqueous Humor Dynamics in Monkeys. Arch Ophthalmol. 1991;109(8):1158-1162. doi:10.1001/archopht.1991.01080080118044