To the Editor.
—The Macular Photocoagulation Study (MPS) demonstrated that argon laser treatment reduced severe visual loss in eyes with extrafoveal choroidal neovascularization (CNV) secondary to senile (age-related) macular degeneration or ocular histoplasmosis syndrome.1 However, recurrent CNV was observed in 59% of treated eyes in the senile macular degeneration study (SMDS), and in 30% of treated eyes in the Ocular Histoplasmosis Study (OHS). Recurrence was accompanied by an increased frequency of severe visual loss. We conducted a study of preoperative fundus characteristics that had not been examined in the MPS to identify clues to the pathogenesis of recurrent CNV that might lead to better treatment of patients.In collaboration with the MPS Fundus Photograph Reading Center (MPS-RC), the following six preoperative angiographic characteristics of CNV and surrounding retina were assessed: fluorescein leakage pattern (classic, smudge, or ooze), amount of fluorescein leakage (minimal to severe), contiguous peripheral blocked fluorescence, degree
Folk JC, Blackhurst DW, Alexander J, Elman MJ, Phillips DA. Pretreatment Fundus Characteristics as Predictors of Recurrent Choroidal Neovascularization. Arch Ophthalmol. 1991;109(9):1193-1194. doi:10.1001/archopht.1991.01080090015002