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Article
November 1991

Familial Aggressive Nevi of the Iris in Childhood

Author Affiliations

From the Institute of Ophthalmology (Drs Paridaens and McCartney), Moorfields Eye Hospital (Messrs Lyons and Hungerford), and St Bartholomew's Hospital (Mr Hungerford), London, England.

Arch Ophthalmol. 1991;109(11):1552-1554. doi:10.1001/archopht.1991.01080110088042
Abstract

• We report the occurrence of amelanotic melanocytic tumors of the iris arising in the second decade of life in two successive generations. Clinically, both tumors enlarged rapidly, with subsequent enucleation of the eye in one patient. In both cases, histologic examination revealed an aggressive iris nevus composed of spindle A cells. Both lesions had similar argyrophilic nucleolar organizing region counts, which may be of prognostic significance. A possible autosomal-dominant pattern of inheritance for this rare tumor is discussed.

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