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December 1991

Potential Toxicity of Mitomycin C

Author Affiliations

Baltimore, Md

Arch Ophthalmol. 1991;109(12):1635. doi:10.1001/archopht.1991.01080120013002

To the Editor.  —Chen et al1 and Palmer2 recently reported on the use of mitomycin C as adjunct chemotherapy during glaucoma filtration surgery. Both investigations followed similar protocols in which the episclera was soaked with a solution of 0.2 to 0.4 mg/mL of mitomycin C for 5 minutes before creating a sclerostomy. The authors concluded that a single, intraoperative application of mitomycin C favorably affected the outcome of trabeculectomy surgery. Although their studies have no concurrent control groups, two randomized controlled trials comparing fluorouracil with topical mitomycin are underway (Association for Research in Vision and Ophthalmology, 1991). No intraocular toxicity was reported using this protocol. Although retinal toxicity has been demonstrated after intravitreal injection of mitomycin C in the rabbit model,3 no studies have addressed intraocular toxicity following injection into the anterior chamber. We studied the intraocular toxicity of mitomycin C following intracameral injection because of the

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