Inflammatory neuritis in the young and middle-aged and ischemic infarction in the late-midlife and older populations, are the most commonly encountered disorders of the optic nerves, glaucoma aside. For decades, these all too frequent clinical syndromes have seemed well defined in terms of chronology of visual loss, patterns of acuity and field depressions, efficacy of therapy, and associated diseases or risk factors. Two important studies published in this issue of the Archives raise questions about "What we thought we already knew."
See also pp 1668 and 1673.
Under the auspices of The National Institutes of Health (Bethesda, Md), 15 clinical centers began recruiting subjects for the Optic Neuritis Treatment Trial (ONTT) in 1988, in an attempt to settle the controversial issue of corticosteroid therapy. While awaiting the conclusions of this therapeutic assessment, the Optic Neuritis Study Group1 reports herein the baseline "clinical profile of acute optic neuritis." This study provides
Glaser JS. Optic Neuritis and Ischemic NeuropathyWhat We Thought We Already Knew. Arch Ophthalmol. 1991;109(12):1666-1667. doi:10.1001/archopht.1991.01080120050023