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January 1992

Pharmacologic TrabeculocanalotomyFacilitating Aqueous Outflow by Assaulting the Meshwork Cytoskeleton, Junctional Complexes, and Extracellular Matrix

Author Affiliations

Madison, Wis

Arch Ophthalmol. 1992;110(1):34-36. doi:10.1001/archopht.1992.01080130036022

The report by Liang et al1 in this issue is significant for two reasons. It illustrates the power of the isolated preparation of organ-cultured human anterior ocular segment in identifying and studying the mechanism of action of potential new antiglaucoma pharmacologic agents. Such studies are usually performed initially in subprimate mammals, then in subhuman primates, and finally in the living human eye. While animal studies are useful, the physiologic and anatomic characteristics of subprimate mammals are often sufficiently different from those of humans to make extrapolation difficult. Primate studies are more relevant, but far more costly and difficult. With increasing concern over the use of animals, especially primates, in biomedical research, these studies have become even more difficult and expensive, threatening the efficient and costeffective development of new antiglaucoma medications. The advent of cell culture technology has brought some relief by allowing study of the effects of pharmacologic agents

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