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March 1992

Suppression of Corneal Neovascularization With Cyclosporine

Author Affiliations

From the Cornea Service, Department of Ophthalmology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill (Drs Lipman and Epstein), and the Ocular Immunology Laboratory, Department of Ophthalmology, University of Illinois at Chicago (Drs Epstein and Hendricks).

Arch Ophthalmol. 1992;110(3):405-407. doi:10.1001/archopht.1992.01080150103037

• We sought to determine if cyclosporine, which has been shown to suppress corneal allograft rejection, could also suppress corneal neovascularization induced by interleukin 2. Thirty A/J mice were treated with daily intramuscular injections of cyclosporine (25 mg/kg in olive oil) for 3 days before and 2 weeks following the intrastromal injection of 0.5 μL (5 IU) of recombinant mouse interleukin 2. Controls received intramuscular injections of olive oil. The mean area of corneal neovascularization 4, 8, and 12 weeks after injection was 9.2, 9.1, and 9.2 mm2, respectively, in controls, and 5.0, 5.2, and 5.2 mm2 in cyclosporinetreated mice (P<.02; Student's t test). Cyclosporine causes a significant reduction in interleukin 2-induced corneal neovascularization that may, in part, account for its ability to prolong corneal allograft survival in high-risk cases.