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April 1992

Tangential Corneal Surface Ablation With 193- and 308-nm Excimer and 2936-nm Erbium-YAG Laser Irradiation

Author Affiliations

From the Departments of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital and New York Hospital-Cornell University Medical Center, New York, NY (Dr Belgorod); US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Md (Dr Ediger and Mr Weiblinger); and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York (Dr Erlandson).

Arch Ophthalmol. 1992;110(4):533-536. doi:10.1001/archopht.1992.01080160111044

• An argon-fluoride excimer laser operating at 193 nm was used to perform tangential, wide-area surface photoablation of the corneas of bovine eyes. Comparisons were made with similar tangential ablations performed with the use of 308-nm xenon chloride excimer laser and qi/gl 2936-nm erbium-YAG laser irradiation to evaluate potential photochemical and thermal effects. Light and transmission electron microscopy of the corneal tissue revealed minimal tissue architectural changes for ablation at 193 nm. The zone of ultrastructural change at the corneal surface with the 193-nm excimer laser was 120 nm thick. The clinical appearance of the corneal surfaces produced by the tangential ablation at 193 nm was the most satisfactory of those with the three wavelengths tested, being macroscopically smooth and glossy.