Clinical trials are expensive and difficult to perform, and yet, when done properly, they are invaluable, for they provide a foundation for informed clinical decisions. Starting with the Diabetic Retinopathy Study, ophthalmologists have benefited from a number of clinical trials that have provided answers to particular treatment-related questions. In this issue of the Archives, there are two reports from the Silicone Oil Study, a multicenter, randomized, clinical trial that was designed to evaluate the benefits and risks of using a long-acting gas bubble or silicone oil as an intraocular tamponade after vitrectomy in eyes with severe proliferative vitreoretinopathy (PVR). Taken together, the reports provide useful information to help guide the selection of an agent for tamponade in the treatment of PVR.
See also pp 770 and 780.
It should be noted, however, that the value of the information depends on an important assumption, namely, that the only difference between the
Haller JA, Campochiaro PA. Oil and Gas on Troubled WatersThe Proliferative Vitreoretinopathy Studies. Arch Ophthalmol. 1992;110(6):768-769. doi:10.1001/archopht.1992.01080180040026