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August 1992

PhXA34-Induced Ocular Hypotension-Reply

Author Affiliations

Uppsala, Sweden
Ume, Sweden

Arch Ophthalmol. 1992;110(8):1042. doi:10.1001/archopht.1992.01080200022005

In Reply.  —We appreciate Dr Kaufman's comment on our recent article1 on the effect of the prostaglandin analogue PhXA34 on aqueous humor dynamics. From that study, as well as previous studies on prostaglandin F-isopropylester, we can conclude that neither prostaglandin F nor its analogue, PhXA34, reduce pressure in the human eye by reducing aqueous flow. In primates, there is ample evidence that increased uveoscleral outflow explains most, if not all, of the reduction in eye pressure.2-3 No clinical technique is available to determine uveoscleral flow, and estimates of changes in uveoscleral flow must be based on indirect evidence. The fact that the change in total outflow facility that we found was too small to explain the observed pressurelowering effect substantiates the assumption that increased uveoscleral outflow is also involved in humans. That was, to us, the most important conclusion that can be drawn from our

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