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November 1992

The Collaborative Corneal Transplantation Studies

Author Affiliations

Chicago, Ill

Arch Ophthalmol. 1992;110(11):1517. doi:10.1001/archopht.1992.01080230015004

To the Editor.  —The results of the Collaborative Corneal Transplantation Studies (CCTS)1 provide exciting and important information that may run counter to the expectations of many. It is important, as the authors point out, to note that the use of topical corticosteroids in the study was significantly more intensive than use both by many corneal surgeons and in prior similar studies. An important conclusion from their study may well be that patients receiving high-risk corneal transplants warrant more intensive topical corticosteroid use. This intensive use of topical corticosteroids may have overwhelmed any potential beneficial effect of HLA-A, -B, and -DR matching. While all of this was well stated in the article, the casual reader reviewing only the abstract may have missed this important point.

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