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November 1992

Polymegethism of the Corneal Endothelium in an Eye With Long-standing Ptosis

Author Affiliations

Amsterdam, the Netherlands

Arch Ophthalmol. 1992;110(11):1529-1530. doi:10.1001/archopht.1992.01080230029010

Because the corneal endothelium is the primary site for the metabolic pump that maintains corneal deturgescence, any change in the morphologic characteristics of endothelial cells is of considerable interest. It has been suggested that the functional reserve of the endothelium may be compromised with more severe cases of polymegethism.

Adverse effects of contact lens wear on physiologic features of the cornea were recently emphasized by the discovery that polymegethism and pleomorphism occurred with contact lens wear.1 These changes could be ascribed to oxygen shortage, carbon dioxide buildup, and pH changes under the lens.1 The same phenomena could be induced in the corneal endothelium of patients suffering from long-standing ptosis, which results in a decreased oxygen tension of approximately one third of the oxygen available under open-eye conditions.2

Report of a Case.  —We report the case of an 85-year-old woman with ptosis of the left eye for more than

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