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January 1993

Tissue Analysis From Two Patients With Premacular Hole Lesions-Reply

Author Affiliations

Baltimore, Md

Arch Ophthalmol. 1993;111(1):22. doi:10.1001/archopht.1993.01090010024011

In Reply.  —We would like to thank Dr Sebag for his interesting comments. He agrees with our suggestion that cells in a layer of attached cortical vitreous may contribute to the formation of macular cysts and holes and he offers the following two speculations: (1) The cells that we observed were hyalocytes rather than retinal pigmented epithelium or glia; and (2) the situation observed by us and others in which there is a layer of cortical vitreous on the surface of the retina with a fluid-filled space just anterior to the retina results from splitting of the cortical vitreous during posterior vitreous detachment, a process that he refers to as vitreoschisis.We agree with Dr Sebag that hyalocytes may be present in the specimens removed from our patients and they could contribute to the development of macular cysts and holes. However, a recent study examining the immunohistochemical staining of hyalocytes

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