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Article
April 1993

Anterior Corneal Disease of Epidermolysis Bullosa Simplex

Author Affiliations

From the Cornea Service, Massachusetts Eye and Ear Infirmary (Dr Adamis) and the Immunology Unit, Schepens Eye Research Institute (Dr Kenyon), Department of Ophthalmology, Harvard Medical School, Boston, Mass (Drs Adamis and Kenyon) and the Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Md (Dr Schein).

Arch Ophthalmol. 1993;111(4):499-502. doi:10.1001/archopht.1993.01090040091039
Abstract

• We report the histopathological findings of the anterior cornea from a patient with skin biopsy-proven epidermolysis bullosa simplex. As seen with light microscopy, the cornea had a fibrocellular pannus deep to a thickened epithelial basement membrane. Transmission electron microscopy of the anterior cornea demonstrated a nonhomogeneous basal epithelial layer with abnormal attachment complexes to an irregular, multilaminar basement membrane. The findings of transmission electron microscopy of the bulbar conjunctiva were normal.

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