Recent reports have documented the efficacy of tissue plasminogen activator in promoting fistula reformation following trabeculectomy1,2 and relieving fibrin-induced pupillary block after retinal procedures.3 We present herein a case in which we successfully used intracameral tissue plasminogen activator in a diabetic patient with neovascular glaucoma who developed a severe anterior chamber fibrin reaction following trabeculectomy with adjunctive mitomycin C.
Report of a Case.
—A 40-year-old black woman with moderate background diabetic retinopathy underwent an uncomplicated cataract extraction using phacoemulsification with implantation of a posterior chamber intraocular lens in the right eye. The postoperative visual acuity was 20/20. Four months after surgery the patient presented with rubeosis iridis, a 5% hyphema, and counting fingers visual acuity. Immediate panretinal photocoagulation was performed.The patient remained in stable condition until 10 months later when she presented with a Serratia marcescens corneal ulcer and hypopyon in the right eye for which she
Olivier MMG, Kupin TH, McDermott ML, Shin DH. Intracameral Tissue Plasminogen Activator in Neovascular Glaucoma. Arch Ophthalmol. 1993;111(5):586. doi:10.1001/archopht.1993.01090050020014