—To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.
—We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.
—In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.
—Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.
Verstraeten TC, Chapman C, Hartzer M, Winkler BS, Trese MT, Williams GA. Pharmacologic Induction of Posterior Vitreous Detachment in the Rabbit. Arch Ophthalmol. 1993;111(6):849-854. doi:10.1001/archopht.1993.01090060139038