The article1 published in the June 1993 issue of the Archives demands a response from one "guinea pig" who believes that his experience with the study has not been accurately portrayed.
First, the article states that "There were no adverse reactions." On the contrary, I, after 4 years of taking the maximum dose of vitamins A and E, was told by research staff that I had high levels of liver enzyme in my blood and should consult a physician. I was then surprised to learn that I was having extreme reactions (nausea, dizziness, and fatigue) to alcohol the day after consumption. I quit drinking once I figured out the relationship, but the fatigue factor did not go away. I quit taking supplements, but for an entire year I was no longer able to work out three times a week. It was a full 2 years before I was back
Clowes DD. A Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa. Arch Ophthalmol. 1993;111(11):1461-1462. doi:10.1001/archopht.1993.01090110018005