The purpose of this study was to determine whether oral pentoxifylline would improve retinal microvascular hemodynamics and blood rheology in patients with diabetes.
Patients were enrolled in a double-masked, placebocontrolled trial of pentoxifylline at 2000 mg/d. Retinal capillary blood velocity and leukocyte density, filterability, viscosity, and fibrinogen content were measured by the bluefield entoptic phenomenon simulation, filtration, rotational viscosimetry, and heat precipitation techniques, respectively, before, during, and after drug therapy.
Treatment with pentoxifylline resulted in a 23.2%, 26.8%, and 37.8% increase in capillary blood flow velocity at 1, 2, and 3 months of therapy, respectively, with a return to pretreatment baseline levels 1 month after cessation of therapy. There were no apparent effects on the remaining variables during treatment.
Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes.
Sonkin PL, Kelly LW, Sinclair SH, Hatchell DL. Pentoxifylline Increases Retinal Capillary Blood Flow Velocity in Patients With Diabetes. Arch Ophthalmol. 1993;111(12):1647–1652. doi:10.1001/archopht.1993.01090120069024