The article by the Silicone Study Group1 published in the June 1992 issue of the Archives represents an immense undertaking of a difficult and complex subject. However, some of the data deserve more explanation.
The postoperative retinal attachment rates for the two modalities are plotted at 1, 3, 6 months, and so on, in their Figure 2.1 Thus, the earliest comparison between retinal attachment rates for perfluoropropane (C3F8) gas and silicone oil is made at 1 month, and it demonstrates considerable differences between the two modalities at that point. If one assumes that all retinas were reattached intraoperatively prior to randomization to C3F8 gas or silicone oil, one needs some explanation for this discrepancy (10% to 30%) in retinal attachment rates between the two groups in the early postoperative period. Although multiple factors can result in failure of retinal attachment,2 this
Peyman GA, Greve MDJ, Millsap CM. Silicone Oil vs Perfluoropropane Gas as a Postoperative Retinal Tamponade. Arch Ophthalmol. 1994;112(6):728-729. doi:10.1001/archopht.1994.01090180026005