[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.155.6. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 1994

Does Preinjection Binding of Indocyanine Green to Serum Actually Improve Angiograms?

Author Affiliations

Baltimore, Md

Arch Ophthalmol. 1994;112(9):1137-1138. doi:10.1001/archopht.1994.01090210021003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

In the September 1993 issue of the Archives, Yoneya and Noyori1 reported that visualization of the choroidal circulation of Japanese monkeys in indocyanine green (ICG) angiograms was improved by binding ICG with autologous serum before injecting it, and they suggested that this method be used in human patients. Before recommending human use of such a technique, however, the potential benefits of that technique must be carefully weighed against its costs in terms of added difficulty and risk to both patient and angiographer. In this case, a significant benefit has not been convincingly demonstrated, making the additional costs in procedure time and risks associated with blood handling and preparation seem unwarranted.

Yoneya and Noyori determined that in vitro equilibrium between ICG dye and a volume of serum albumin required 10 minutes, and since it is well known that fluorescence of protein-bound ICG is considerably greater than that of ICG in

First Page Preview View Large
First page PDF preview
First page PDF preview
×