We examined the cornea of the nonfunctional left eye of a 46-year-old man, which was enucleated 8 months following explantation of an ICR (Intrastromal Corneal Ring). Corneal haze was confined to the midstroma, in the region of the tissue from which the ICR had been removed. Stromal tissue in this area was subtly compressed and irregular. Electron microscopy in conjunction with cuprolinic blue staining demonstrated an unremarkable proteoglycan population and several areas of slight collagen disruption at midstromal depth at the site of the previously implanted ICR. We conclude that disruptions of the corneal stroma that remain 8 months following explantation of an ICR are minimal.
Quantock AJ, Kincaid MC, Schanzlin DJ. Stromal Healing Following Explantation of an ICR (Intrastromal Corneal Ring) From a Nonfunctional Human Eye. Arch Ophthalmol. 1995;113(2):208-209. doi:10.1001/archopht.1995.01100020092036