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March 1995

The Galactosemic DogA Valid Model for Both Early and Late Stages of Diabetic Retinopathy

Author Affiliations

Detroit, Mich

Arch Ophthalmol. 1995;113(3):275-276. doi:10.1001/archopht.1995.01100030029016

AN ACCURATE animal model of a human disease can help us to understand the pathogenesis of the disease, to study its cellular and molecular mechanisms of progression, and to test new therapeutic approaches before they are ready for evaluation in human subjects. The model of diabetic retinopathy in the long-term galactosemic dog, introduced by Engerman and Kern1 in 1984, is one of the best animal models now available in ophthalmic research. After 3 to 5 years on a diet containing 30% galactose, these animals accurately reproduce the lesions of early diabetic retinopathy in humans, and they do so following chronic elevation of an aldohexose that is structurally similar to glucose but does not enter into many of the biochemical pathways by which glucose is metabolized. In this issue of the Archives, Engerman and Kern2 and Kador et al3 report important new findings using this model that appear

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