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Article
October 1995

Retinal Toxic Effects Following Inadvertent Intraocular Injection of Celestone Soluspan

Author Affiliations

Durham, NC

Arch Ophthalmol. 1995;113(10):1230-1231. doi:10.1001/archopht.1995.01100100018011
Abstract

Periocular injection of corticosteroids frequently is used to reduce the intraocular inflammation that is associated with surgery and various forms of uveitis. Inadvertent globe perforation and intraocular corticosteroid injection are serious complications and may result in retinal detachment with proliferative vitreoretinopathy.1,2 There is experimental evidence that ocular toxic effects are dependent on the particular vehicle of the commercially available corticosteroid preparation, with the vehicle of Celestone Soluspan (betamethasone acetate and betamethasone sodium phosphate preserved in benzalkonium chloride) demonstrating the most pronounced toxic effects.3 We report a case involving inadvertent intraocular injection of Celestone Soluspan following sutureless cataract surgery that resulted in severe retinal toxic effects and the subsequent development of rhegmatogenous retinal detachment.

Report of a Case.  A 59-year-old woman underwent phacoemulsification with implantation of a posterior chamber intraocular lens in the left eye. Anesthesia was achieved using peribulbar injections of 2% lidocaine hydrochloride followed by

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