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November 1995

Treatment of Cytomegalovirus Retinitis With Intraocular Sustained-Release Ganciclovir Implant-Reply

Author Affiliations

Atlanta, Ga
Bethesda, Md
Madison, Wis
Bethesda, Md

Arch Ophthalmol. 1995;113(11):1355. doi:10.1001/archopht.1995.01100110014004

In reply  We thank Dr Friedberg for her letter and the important questions she raises. Thirty-seven of the 39 eyes treated with an implant in our study had only peripheral retinitis; two eyes had some involvement of the posterior pole. Twenty eyes had less than 10% of the retina involved by CMV, 12 eyes had 10% to 25% retinal involvement, and seven eyes had more than 25% involvement. Of the eyes that developed retinal detachment, two had less than 10% involvement, four had 10% to 25% involvement, and one had more than 25% involvement. At the time of detachment, the CMV retinitis was inactive in all cases.Given our limited sample size, definitive conclusions regarding the risk for retinal detachment are not possible. Although most patients in our study had relatively small CMV lesions that may be associated with a lower risk for retinal detachment, nearly all lesions were located

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