We have recently reported a 3.3% recurrence rate for pterygium after the intraoperative use of 0.1-mg/mL mitomycin as an adjunctive therapy to surgery.1 However, all the cases showed delayed conjunctival wound healing, which could create a predisposition to infectious scleritis. Fluorouracil, a weaker antiproliferative drug,2 might be a valid and safe alternative to mitomycin. Because we know of no studies using placebo as a control, we undertook a randomized double-masked, placebo-controlled prospective study comparing simple excision of primary pterygium with excision plus a single low-dose intraoperative application of fluorouracil to evaluate the effectiveness and safety of fluorouracil.
Ethical approval was obtained from the La Fe Hospital (Valencia, Spain) Ethics Committee and informed consent was signed by all patients. All the procedures were performed by two surgeons (M.J.M.,J.C. -P.). Pterygia were excised leaving a bare sclera measuring 3×4 mm. Patients were randomized in a masked fashion to receive a
Maldonado MJ, Cano-Parra J, Navea-Tejerina A, Cisneros AL, Vila E, Menezo JL. Inefficacy of Low-Dose Intraoperative Fluorouracil in the Treatment of Primary Pterygium. Arch Ophthalmol. 1995;113(11):1356-1357. doi:10.1001/archopht.1995.01100110016008