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January 1996

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma-Reply

Author Affiliations

Charleston, SC

Arch Ophthalmol. 1996;114(1):105. doi:10.1001/archopht.1996.01100130101026

In reply  We appreciate Dr Wilson's interest in our article, and we wish to comment on the issues he raised. Since a pathophysiologic correlation of confluent deep white matter lesions with small-vessel ischemia or arteriolosclerosis exists,1,2 this implies that evidence of ischemic injury may be drawn from MRI. We did not base our diagnosis of ischemia on cognitive defects but merely stated that a clinical correlation has been made to the presence of confluent deep white matter lesions. Although a total cross-sectional area would be an interesting way to measure the defects, this does not have to be performed to make the diagnosis or a statistical analysis.1,2With regard to age, as stated in the paper, we evaluated if our confluent deep white matter lesions were a function only of age. We found that the average age of people with multiple isolated (clinically unimportant) lesions was similar to

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