Fluorescein and, more recently, indocyanine green angiography generally are used in the detection of choroidal neovascular membranes, the major cause of decreased visual acuity in age-related macular degeneration. The findings reported herein indicate that infrared light imaging (at 795 nm1) may also be useful in the detection of well-defined neovascular membranes.
Infrared images and fluorescein angiograms were obtained by means of a scanning laser ophthalmoscope (Scanning Laser Opthalmoscope 101, Rodenstock Instrument GmbH, Ottobrunn-Riemerling, Germany), using a 785-nm diode laser in confocal mode with different apertures for infrared images and a 488-nm argon laser with a 530-nm filter for fluorescein angiography. The fluorescein angiograms of 10 consecutive patients with well-defined neovascular membranes were compared with images obtained using infrared light.
In all of these cases, the infrared images of the membrane showed a white contour that corresponded fairly closely in size and shape to that demonstrated by fluorescein angiography (Figure
Staurenghi G, Aschero M, La Capria A, Gonnella P, Orzalesi N. Visualization of Neovascular Membranes With Infrared Light Without Dye Injection by Means of a Scanning Laser Ophthalmoscope. Arch Ophthalmol. 1996;114(3):365. doi:10.1001/archopht.1996.01100130361042