This is the first report to our knowledge of Candida endophthalmitis complicating Job syndrome, and it serves to remind clinicians that the differential diagnosis of severe panuveitis needs to include endogenous endophthalmitis in patients with immunodeficiency states.
Report of a Case.
A 24-year-old woman with an established diagnosis of Job syndrome came to our unit for a second opinion. The vision in her right eye had been reduced for several weeks. Treatment for toxoplasma retinochoroiditis had already been given, on the basis of clinical appearance, with oral prednisolone acetate and clindamycin hydrochloride, but treatment with clindamycin had been stopped after 1 week because she developed diarrhea. On initial examination, she complained of intermittent ache in her right eye, and her vision was reduced to hand movements. There was a relative afferent pupillary defect and a severe panuveitis, with cells in the anterior chamber and marked vitreous opacities. A white retinochoroidal
Haslett RS, Moriarty AP, Vijayadurai P, McGalliard JN, Chandna A. Candida Endophthalmitis in Job Syndrome. Arch Ophthalmol. 1996;114(5):617-618. doi:10.1001/archopht.1996.01100130609023