To evaluate the intraocular pressure (IOP)-reducing effect and the side effects of latanoprost (PhXA41), a new phenyl-substituted prostaglandin F2α-isopropyl ester analogue, in patients with elevated IOP, using timolol maleate as the reference drug.
A total of 184 patients with primary open-angle glaucoma or ocular hypertension at 35 medical centers participated in this randomized double-masked study. The patients were randomized to receive either 0.005% latanoprost once daily or 0.5% timolol maleate twice daily, for a period of 12 weeks. Intraocular pressure was measured 24 hours after the administration of timolol, at 2, 4, 8, and 12 weeks of treatment.
Latanoprost reduced IOP at the end of 12 weeks by 6.2±2.7 mm Hg (mean±SD) (26.8%), while timolol reduced IOP by 4.4±2.3 mm Hg (19.9%). At all visits latanoprost reduced IOP significantly more than timolol did. The main ocular side effects observed in both groups were conjunctival hyperemia and smarting. The main systemic side effect was a reduced pulse rate, which occurred in patients treated with timolol.
The results of this study demonstrated that 0.005% latanoprost taken once daily is well tolerated and more effective in reducing IOP than 0.5% timolol taken twice daily. Thus, latanoprost may become an important choice for the medical treatment of glaucoma.
Mishima HK, Masuda K, Kitazawa Y, Azuma I, Araie M. A Comparison of Latanoprost and Timolol in Primary Open-angle Glaucoma and Ocular HypertensionA 12-Week Study. Arch Ophthalmol. 1996;114(8):929-932. doi:10.1001/archopht.1996.01100140137004