The recently published EVS presents the results of a randomized prospective clinical trial comparing 4 different initial treatment strategies for endophthalmitis following primary cataract surgery or secondary intraocular lens implantation.1 Although the data represent a major contribution to our knowledge of the treatment outcomes of these approaches, the conclusions in the abstract go far beyond the data presented in the article.
Using the 4 major study outcomes (visual acuity ≥20/40, ≥20/100, ≥5/200, and media clarity), the EVS demonstrated no harmful effects in the 3-port pars plana vitrectomy group compared with the needle-tap or vitrectomy-biopsy group. Furthermore, the EVS data showed the following beneficial effects in the 3-port pars plana vitrectomy group compared with the needle-tap or vitrectomy-biopsy group: (1) improved media clarity at all follow-up examinations (statistically significant at 3 months); (2) lower rates of retinal detachment; (3) lower rates of persistent positive intraocular cultures (data presented at the
Flynn HW, Meredith TA. The Endophthalmitis Vitrectomy Study. Arch Ophthalmol. 1996;114(8):1027-1028. doi:10.1001/archopht.1996.01100140233033