To assess the incidence of uveitis associated with topical β-blockers.
Retrospective cohort study.
A computerized database of a health maintenance organization was used to identify patients who were prescribed metipranolol or other β-blockers.
Two groups: 1928 patients using 0.3% metipranolol and 3903 patients using other β-blockers.
Main Outcome Measure:
Cases of uveitis were identified by noting a prescription of a topical corticosteroid and then conducting a chart review.
No cases of uveitis were identified among the 5831 patients. The upper limits of the 95% confidence intervals for the incidence of uveitis in cohorts of this size are 1.87 cases per 1000 person-years of exposure for metipranolol and 1.38 for other β-blockers.
Drug-induced uveitis from metipranolol or other β-blocker administration is a rare event, even if a causal relationship exists.
Beck RW, Moke P, Blair RC, Nissenbaum R. Uveitis Associated With Topical β-Blockers. Arch Ophthalmol. 1996;114(10):1181-1182. doi:10.1001/archopht.1996.01100140381002