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November 1996

Results of Combined Chemotherapy and Radiotherapy for Advanced Intraocular Retinoblastoma

Author Affiliations

From the Departments of Paediatric Oncology (Dr Kingston), Ophthalmology (Dr Hungerford), and Radiotherapy (Dr Plowman), St Bartholomew's Hospital, London, England; and the Department of Ophthalmology, Center for Vision Research, Case Western University, Cleveland, Ohio (Dr Madreperla).

Arch Ophthalmol. 1996;114(11):1339-1343. doi:10.1001/archopht.1996.01100140539004

Objective:  To determine the visual and anatomical results and survival after combined chemotherapy and whole eye radiotherapy for patients with bilateral Reese-Ellsworth group V retinoblastoma.

Setting:  A national referral center for retinoblastoma.

Patients:  Fourteen patients with bilateral Reese-Ellsworth group V retinoblastoma seen between March 1, 1989, and April 30, 1995, were treated.

Interventions:  Patients were treated with chemotherapy (using carboplatin, etoposide, and vincristine) and whole eye radiotherapy (40-44 Gy in 20-22 equivalent fractions). A medical record review was performed to determine outcomes.

Main Outcome Measures:  Survival, eye preservation rate, and visual acuity.

Results:  Two patients died, 1 from a primitive neuroectodermal tumor and the other from the meningeal spread of retinoblastoma. Four eyes were enucleated primarily because of severe disease at presentation. Of the remaining 20 eyes, 6 required enucleation. The disease recurred in 4 of those patients, and neovascular glaucoma developed in 2 patients. Of the 12 surviving children, 5 have a visual acuity better than 1/60 in at least 1 eye.

Conclusion:  Although most of the treated group V eyes could be salvaged with chemotherapy plus radiotherapy, the resultant visual acuity was often poor.