March 1997

Going Forward to Work Backward

Author Affiliations

New York, NY

Arch Ophthalmol. 1997;115(3):404-406. doi:10.1001/archopht.1997.01100150406015

In this issue of the Archives, Andersen et al1 describe 4 families with autosomal dominant pigment dispersion syndrome (PDS) affecting a total of 28 of 54 persons. The gene in these families mapped to the telomeric end of the long arm of chromosome 7 (7q35-q36). Not only does this important achievement finally show that this fascinating entity is a true disease in its own right, separate from autosomal dominant juvenile open-angle glaucoma or adult-onset primary (idiopathic) open-angle glaucoma, it also opens the door for the eventual initiation of studies to answer numerous questions that have arisen during the past 2 decades and to verify or discard several features possibly associated with PDS that remain as yet unproved clinical impressions. Although the basic abnormality in this hereditary disorder remains unknown, we are on the verge of a coherent overall explanation of its pathogenesis and pathophysiological features.

ESSENTIAL FACTS  Pigment dispersion

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